MAPK1 CLIA Kit for Human(Homo sapiens) | EIAab.comMAPK1 CLIA Kit for Human(Homo sapiens)

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MAPK1 (Gene name),

Mitogen-activated protein kinase 1 (Protein name ), MK01_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MAPK1(ERK2;PRKM1;PRKM2);

Protein name:

Mitogen-activated protein kinase 1(MAP kinase 1;MAPK 1);

Alternative:

Extracellular signal-regulated kinase 2(ERK-2);ERT1;Mitogen-activated protein kinase 2(MAP kinase 2;MAPK 2);MAP kinase isoform p42(p42-MAPK);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with MORG1 (By similarity). Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine-kinase activity. Interacts with its substrates HSF4 and ARHGEF2. Interacts (phosphorylated form) with CAV2 ('Tyr-19'-phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation (By similarity). Interacts with NISCH. Interacts with ARRB2. Interacts with ADAM15. Interacts with isoform 1 of NEK2.

Function:

Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.

Subcellular Location:

Nucleus Cytoplasm cytoskeleton centrosome

Protein Attributes:

Sequence length:

360

Sequence:

50:

100:

150:

200:

250:

300:

350:

360:

TARFQPGYRS |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.431850

SMR:

P28482

KEGG:

hsa:5594

String:

P28482

Pfam:

PF00069

STRING:

9606.ENSP00000215832

MIM:

176948

Uniprot:

P28482

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ELISA Kit for Human MAP kinase 1

Cat.:

E1206m

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96T

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ELISA Kit for Human MAP kinase 1

Cat.:

E1206r

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96T

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ELISA Kit for Human MAP kinase 1

Cat.:

E1206h

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96T

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ELISA Kit for Human MAP kinase 1

Cat.:

E1206b

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96T

CLIA Kit for Human MAP kinase 1

Cat.:

U1206h

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96T

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CLIA Kit for Human MAP kinase 1

Cat.:

U1206m

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MSDS:

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Packing:

96T

CLIA Kit for Human MAP kinase 1

Cat.:

U1206r

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MSDS:

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Packing:

96T

CLIA Kit for Human MAP kinase 1

Cat.:

U1206b

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96T

Polyclonal Antibody for Human MAP kinase 1

Cat.:

P1206Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human MAP kinase 1

Cat.:

P1206Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human MAP kinase 1

Cat.:

P1206Rb-r

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40ug/0.2ml

Monoclonal Antibody for Human MAP kinase 1

Protein for Human MAP kinase 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs."
Owaki H. , Makar R. , Boulton T.G. , Cobb M.H. , Geppert T.D.
Biochem. Biophys. Res. Commun.182:1416-1422(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Heterogeneous expression of four MAP kinase isoforms in human tissues."
Gonzalez F.A. , Raden D.L. , Rigby M.R. , Davis R.J.
FEBS Lett.304:170-178(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"Identification of dominant negative Erk1/2 variants in cancer cells."
Cheng H. , Ren S. , Qiu R. , Wang M. , Feng Y.H.
Submitted (2006-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);ALTERNATIVE SPLICING
4.

"The DNA sequence of human chromosome 22."
Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Lung.
6.

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-15;ACETYLATION AT ALA-2
tissue: Platelet.
7.

"ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation."
Sgouras D.N. , Athanasiou M.A. , Beal G.J. Jr. , Fisher R.J. , Blair D.G. , Mavrothalassitis G.J.
EMBO J.14:4781-4793(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF ERF
8.

"3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region."
Sithanandam G. , Latif F. , Duh F.-M. , Bernal R. , Smola U. , Li H. , Kuzmin I. , Wixler V. , Geil L. , Shrestha S. , Lloyd P.A. , Bader S. , Sekido Y. , Tartof K.D. , Kashuba V.I. , Zabarovsky E.R. , Dean M. , Klein G. , more...
Mol. Cell. Biol.16:868-876(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF MAPKAPK3
9.

"Human immunodeficiency virus type 1 Nef binds directly to LCK and mitogen-activated protein kinase, inhibiting kinase activity."
Greenway A.L. , Azad A. , Mills J. , McPhee D.A.
J. Virol.70:6701-6708(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIV-1 NEF
10.

"MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase."
Ni H. , Wang X.S. , Diener K. , Yao Z.
Biochem. Biophys. Res. Commun.243:492-496(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF MAPKAPK5
11.

"Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB."
Deak M. , Clifton A.D. , Lucocq J.M. , Alessi D.R.
EMBO J.17:4426-4441(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF RPS6KA5/MSK1
12.

"Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor."
Niu H. , Ye B.H. , Dalla-Favera R.
Genes Dev.12:1953-1961(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF BCL6
13.

"Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase."
Camps M. , Nichols A. , Gillieron C. , Antonsson B. , Muda M. , Chabert C. , Boschert U. , Arkinstall S.
Science280:1262-1265(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DUSP6;FUNCTION
14.

"Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway."
Todd J.L. , Tanner K.G. , Denu J.M.
J. Biol. Chem.274:13271-13280(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEPHOSPHORYLATION BY DUSP3
15.

"ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry."
Cruzalegui F.H. , Cano E. , Treisman R.
Oncogene18:7948-7957(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF ELK1
16.

"Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation."
Brondello J.M. , Pouyssegur J. , McKenzie F.R.
Science286:2514-2517(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF DUSP1
17.

"The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells."
Scheper G.C. , Morrice N.A. , Kleijn M. , Proud C.G.
Mol. Cell. Biol.21:743-754(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS MKNK2 KINASE
18.

"Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38."
Ouwens D.M. , de Ruiter N.D. , van der Zon G.C. , Carter A.P. , Schouten J. , van der Burgt C. , Kooistra K. , Bos J.L. , Maassen J.A. , van Dam H.
EMBO J.21:3782-3793(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF ATF2
19.

"IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation."
Garcia J. , Ye Y. , Arranz V. , Letourneux C. , Pezeron G. , Porteu F.
EMBO J.21:5151-5163(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF IER3;INTERACTION WITH IER3;ENZYME REGULATION
20.

"Insulin receptor substrate 4 associates with the protein IRAS."
Sano H. , Liu S.C.H. , Lane W.S. , Piletz J.E. , Lienhard G.E.
J. Biol. Chem.277:19439-19447(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NISCH
21.

"EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2."
Wu Y. , Chen Z. , Ullrich A.
Biol. Chem.384:1215-1226(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF FRS2
22.

"Activation of ERK induces phosphorylation of MAPK phosphatase-7, a JNK specific phosphatase, at Ser-446."
Masuda K. , Shima H. , Katagiri C. , Kikuchi K.
J. Biol. Chem.278:32448-32456(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF DUSP16
23.

"Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK."
Allan L.A. , Morrice N. , Brady S. , Magee G. , Pathak S. , Clarke P.R.
Nat. Cell Biol.5:647-654(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CASP9
24.

"Nek2A specifies the centrosomal localization of Erk2."
Lou Y. , Xie W. , Zhang D.F. , Yao J.H. , Luo Z.F. , Wang Y.Z. , Shi Y.Y. , Yao X.B.
Biochem. Biophys. Res. Commun.321:495-501(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH NEK2
25.

"Signal transduction via the stem cell factor receptor/c-Kit."
Ronnstrand L.
Cell. Mol. Life Sci.61:2535-2548(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN KIT SIGNALING
26.

"Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin."
Mitsushima M. , Suwa A. , Amachi T. , Ueda K. , Kioka N.
J. Biol. Chem.279:34570-34577(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF SORBS3
27.

"MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol."
Domina A.M. , Vrana J.A. , Gregory M.A. , Hann S.R. , Craig R.W.
Oncogene23:5301-5315(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF MCL1
28.

"Phosphorylation of Grb10 by mitogen-activated protein kinase: identification of Ser150 and Ser476 of human Grb10zeta as major phosphorylation sites."
Langlais P. , Wang C. , Dong L.Q. , Carroll C.A. , Weintraub S.T. , Liu F.
Biochemistry44:8890-8897(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF GRB10
29.

"Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK."
Chen C.H. , Wang W.J. , Kuo J.C. , Tsai H.C. , Lin J.R. , Chang Z.F. , Chen R.H.
EMBO J.24:294-304(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF DAPK1;SUBCELLULAR LOCATION;INTERACTION WITH DAPK1
30.

"Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death."
Hong J.W. , Ryu M.S. , Lim I.K.
J. Biol. Chem.280:21256-21263(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF BTG2
31.

"Regulation of Raf-1 by direct feedback phosphorylation."
Dougherty M.K. , Muller J. , Ritt D.A. , Zhou M. , Zhou X.Z. , Copeland T.D. , Conrads T.P. , Veenstra T.D. , Lu K.P. , Morrison D.K.
Mol. Cell17:215-224(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF RAF1
32.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
33.

"ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA."
Fujishiro S.H. , Tanimura S. , Mure S. , Kashimoto Y. , Watanabe K. , Kohno M.
Biochem. Biophys. Res. Commun.368:162-167(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARHGEF2
34.

"Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26."
Hu Y. , Mivechi N.F.
Mol. Cell. Biol.26:3282-3294(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH HSF4
35.

"ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation."
Degoutin J. , Vigny M. , Gouzi J.Y.
FEBS Lett.581:727-734(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
36.

"Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKs."
Xu T.-R. , Baillie G.S. , Bhari N. , Houslay T.M. , Pitt A.M. , Adams D.R. , Kolch W. , Houslay M.D. , Milligan G.
Biochem. J.413:51-60(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB2
37.

"Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma."
Zhong J.L. , Poghosyan Z. , Pennington C.J. , Scott X. , Handsley M.M. , Warn A. , Gavrilovic J. , Honert K. , Kruger A. , Span P.N. , Sweep F.C. , Edwards D.R.
Mol. Cancer Res.6:383-394(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ADAM15
38.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
39.

"Identification and characterization of a general nuclear translocation signal in signaling proteins."
Chuderland D. , Konson A. , Seger R.
Mol. Cell31:850-861(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-246 AND SER-248;INTERACTION WITH IPO7;SUBCELLULAR LOCATION
40.

"Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction."
Vomastek T. , Iwanicki M.P. , Burack W.R. , Tiwari D. , Kumar D. , Parsons J.T. , Weber M.J. , Nandicoori V.K.
Mol. Cell. Biol.28:6954-6966(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF TPR;INTERACTION WITH TPR;MUTAGENESIS OF LYS-54; 176-PRO--ASP-179; THR-185; TYR-187; LEU-234; ASP-318 AND ASP-321
41.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-185 AND TYR-187;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
42.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
43.

"Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling."
Hu S. , Xie Z. , Onishi A. , Yu X. , Jiang L. , Lin J. , Rho H.-S. , Woodard C. , Wang H. , Jeong J.-S. , Long S. , He X. , Wade H. , Blackshaw S. , Qian J. , Zhu H.
Cell139:610-622(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A TRANSCRIPTIONAL REPRESSOR;DNA-BINDING
44.

"The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction."
Sun J. , Pedersen M. , Ronnstrand L.
J. Biol. Chem.284:11039-11047(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN KIT SIGNALING PATHWAY;PHOSPHORYLATION
45.

"Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases."
Sacco F. , Tinti M. , Palma A. , Ferrari E. , Nardozza A.P. , Hooft van Huijsduijnen R. , Takahashi T. , Castagnoli L. , Cesareni G.
J. Biol. Chem.284:22048-22058(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-187;DEPHOSPHORYLATION AT TYR-187 BY PTPRJ;MUTAGENESIS OF ASP-318
46.

"Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration."
Won M. , Park K.A. , Byun H.S. , Kim Y.R. , Choi B.L. , Hong J.H. , Park J. , Seok J.H. , Lee Y.H. , Cho C.H. , Song I.S. , Kim Y.K. , Shen H.M. , Hur G.M.
J. Hepatol.51:67-76(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-29 BY SGK1;INTERACTION WITH SGK1
47.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-284;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
48.

"A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy."
Lorenz K. , Schmitt J.P. , Schmitteckert E.M. , Lohse M.J.
Nat. Med.15:75-83(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-190;ENZYME REGULATION;SUBUNIT;SUBCELLULAR LOCATION
49.

"The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions."
Yoon S. , Seger R.
Growth Factors24:21-44(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
50.

"The ERK signaling cascade--views from different subcellular compartments."
Yao Z. , Seger R.
BioFactors35:407-416(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION;REVIEW ON SUBCELLULAR LOCATION
51.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-185 AND TYR-187;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
52.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
53.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
54.

"The ERK cascade: distinct functions within various subcellular organelles."
Wortzel I. , Seger R.
Genes Cancer2:195-209(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ENZYME REGULATION;REVIEW ON FUNCTION
55.

"Mitogen-activated protein kinase extracellular signal-regulated kinase 2 phosphorylates and promotes Pin1 protein-dependent promyelocytic leukemia protein turnover."
Lim J.H. , Liu Y. , Reineke E. , Kao H.Y.
J. Biol. Chem.286:44403-44411(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PML
56.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-185 AND TYR-187;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
57.

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
58.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
59.

"Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2."
Reiterer V. , Fey D. , Kolch W. , Kholodenko B.N. , Farhan H.
Proc. Natl. Acad. Sci. U.S.A.110:E2934-2943(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STYX
60.

"A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase."
Fox T. , Coll J.T. , Xie X. , Ford P.J. , Germann U.A. , Porter M.D. , Pazhanisamy S. , Fleming M.A. , Galullo V. , Su M.S. , Wilson K.P.
Protein Sci.7:2249-2255(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH INHIBITOR
61.

"Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex."
Ohori M. , Kinoshita T. , Okubo M. , Sato K. , Yamazaki A. , Arakawa H. , Nishimura S. , Inamura N. , Nakajima H. , Neya M. , Miyake H. , Fujii T.
Biochem. Biophys. Res. Commun.336:357-363(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) IN COMPLEX WITH INHIBITOR
62.

"Crystal structure of human ERK2 complexed with a pyrazolo[3,4-c]pyridazine derivative."
Kinoshita T. , Warizaya M. , Ohori M. , Sato K. , Neya M. , Fujii T.
Bioorg. Med. Chem. Lett.16:55-58(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) IN COMPLEX WITH INHIBITOR
63.

"Role of a cysteine residue in the active site of ERK and the MAPKK family."
Ohori M. , Kinoshita T. , Yoshimura S. , Warizaya M. , Nakajima H. , Miyake H.
Biochem. Biophys. Res. Commun.353:633-637(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) IN COMPLEX WITH INHIBITOR
64.

"Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors."
Aronov A.M. , Baker C. , Bemis G.W. , Cao J. , Chen G. , Ford P.J. , Germann U.A. , Green J. , Hale M.R. , Jacobs M. , Janetka J.W. , Maltais F. , Martinez-Botella G. , Namchuk M.N. , Straub J. , Tang Q. , Xie X.
J. Med. Chem.50:1280-1287(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 2-359 IN COMPLEX WITH INHIBITOR
65.

"Structural basis of substrate recognition by hematopoietic tyrosine phosphatase."
Critton D.A. , Tortajada A. , Stetson G. , Peti W. , Page R.
Biochemistry47:13336-13345(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 186-191;PHOSPHORYLATION AT TYR-187
66.

"Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control."
Aronov A.M. , Tang Q. , Martinez-Botella G. , Bemis G.W. , Cao J. , Chen G. , Ewing N.P. , Ford P.J. , Germann U.A. , Green J. , Hale M.R. , Jacobs M. , Janetka J.W. , Maltais F. , Markland W. , Namchuk M.N. , Nanthakumar S. , Poondru S. , more...
J. Med. Chem.52:6362-6368(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH INHIBITOR

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